use phage in a sentence.
How do you prevent the phage from evolving to target the human cells?
Glad to see phage therapy mentioned.
That's not the only reason no-one uses phage therapy - there's also a strong cultural resistance in the west.
With extensive sequencing-based environmental monitoring, as we're starting to see in many western countries, we can detect the evolution of new bacterial and phage strains in near real-time and isolate the phage to treat the pathogens.
A nitpick, a phage is a virus that targets bacteria.
I wonder if phage therapy will be the best future treatment of bacterial infections.
Additionally, don't forget that phages are not all lytic and not all are effective (i.
So while phages can be useful (I never said they weren't) their use is limited and has it's own drawbacks.
The big problems with phage are: 1) Narrow spectrum 2) Readily cleared by the immune system 3) Bad at killing bacteria in comparison to antibiotics.
It's easy to make highly pure phage.
At least one phage is dangerous, but I'm not aware of any other examples.
Finally, with regards to safety, phage are currently in use as an anti-microbial again listeria.
It seems the West should pay more attention to phage therapy.
Bottom line: none of the research done on phage therapy has indicated that this is a blocker.
So far, the main blockers to the development of phage therapy are: the FDA doesn't know how to approve them, companies don't know how to patent them, and people freak out when a doctor says: "Now I'm going to give you a virus...
It's unfortunate that regulatory environment in the US is not more favorable for advancing phage therapy.
Many years ago, I remember seeing a BBC documentary about phages that were (and are) used in Russia and former Soviet states in place of antibiotics.
You don't take phages back out of the person, so the source is not under evolutionary pressure to affect humans -- each batch is "seeing" humans for the first time.
We'll probably end up using phages because we won't have any other choice.
The bar has certainly been met with regards to phage as a food additive: The error rate of an E.
It isn't like a phage is going to jump Kingdoms and start predating you instead of the preferred host.
Additionally there are new treatments being investigated such as phage therapy (albeit this more of a revival) heavy metals and bacteriocins (protein based).
Fair enough, but I suspect "thousands of years" of evolution may come very quickly if phages were to be used half as widely as antibiotics are.
Besides that, not all of the cells bacteriophages could harmfully target are human cells.